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A new era began to materialise, however, by the late 1950s as a result of advances in peptide chemistry, fraction technology and the development of modern methods for the purification of peptides (Creutzfeldt
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doi: 10.1056/NEJMoa1612917 16 GreenJBHernandezAFD’AgostinoRBGrangerCBJanmohamedSJonesNPet al